Science & Validation

Built Around Scientific Reliability

MolVerity AI evaluates more than predictive accuracy. Predictive discrimination alone is not sufficient for scientific decision support; calibration, uncertainty, chemical-domain coverage and robustness under distribution shift also matter.

Methodological Principles

How Models Are Developed and Evaluated

01

Endpoint-specific modeling

Each toxicity endpoint is modeled to reflect its biological endpoint and dataset.

02

Scaffold-aware train/test separation

Evaluation accounts for structural scaffolds to reduce overly optimistic estimates.

03

Repeated evaluation

Models are assessed across repeated runs rather than relying on one split.

04

Probability calibration

Raw model outputs are calibrated to improve probabilistic interpretability.

05

Uncertainty estimation

Ensemble disagreement is quantified alongside predictions.

06

Applicability-domain assessment

Each prediction is evaluated against represented chemistry.

07

Out-of-distribution detection

Molecules outside the model-development domain are flagged.

08

Explicit abstention

The platform can decline a forced prediction when support is insufficient.

09

External validation

Model behavior is assessed on held-out external data where available.

10

Bootstrap confidence intervals

Performance estimates include uncertainty ranges.

11

Transparent limitations

Known endpoint and model limitations are documented.

12

Reproducibility & versioning

Model releases and predictions are designed for traceability.

Documentation

Scientific Documentation

Formal documentation will be published as it becomes available. This page does not present fabricated performance claims.

Publications

To be published.

Validation Reports

To be published.

Model Cards

To be published.

Datasets

To be published.

Benchmark Results

To be published.

Scientific Documentation

To be published.

Scientific Collaboration

Talk to the Science Team

Reach out for methodology questions, academic collaboration or available documentation.